Localization of an Ia-bearing glomerular cell in the mesangium.

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Abstract
Using trypsin to render intact, isolated rat glomeruli permeable to antibody, and using an EM immunoperoxidase technique, a phagocytic immunologically-relevant cell bearing Ia determinants to the renal mesangium were localized. There are at least 2 functionally distinct cell types in the renal mesangium: one is a contractile smooth musclelike cell, and the other a phagocytic cell that bears immunologically-relevant surface determinants.