Trimethoprim-Sulfamethoxazole in the Treatment of Bacteriuria in Women

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Abstract
Trimethoprim (TMP) and the combination of TMP with sulfamethoxazole (SMZ) were successful in treating urinary infection associated with the dysuria-frequency syndrome and bacteriuria in pregnancy. Both drugs appeared to be more successful than other substances in pregnant patients with bacteriuria who had already failed to respond to treatment. A double-blind trial using ampicillin, cephalexin, TMP-SMZ, and TMP in the treatment of urinary infection was carried out. One hundred forty-nine courses of treatment were given to pregnant women and 107 to patients with dysuria and frequency seen by general practitioners. A considerable variation in response was found. In patients from general practice with infection and in pregnant women with bacteriuria, TMP alone was at least as effective as the other three compounds. There was a significantly lower incidence of side effects with TMP alone. There is no strong evidence to suggest that either TMP-SMZ or TMP causes a serious risk of teratogenicity. No gross hematologic disorder was found following the use of TMP-SMZ.

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