IRIDIUM-191 ANGIOCARDIOGRAPHY FOR THE DETECTION AND QUANTITATION OF LEFT-TO-RIGHT SHUNTING

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (12) , 1151-1157
Abstract
An 191Os .fwdarw. 191Ir generator that can deliver multiple doses of 191mIr for 1st-pass radionuclide angiography was developed. 191mIr has a physical half-life [t1/2] of 4.96 s and decays with emission of 65 keV and 129 keV photons in 58 and 30% abundance, respectively. Using a .gamma. camera, 191mIr radionuclide angiography was carried out, in dogs and 10 patients, for the detection and quantitation of left-to-right shunting. In a 1 yr old patient, 25 mCi of 191mIr results in a whole-body radiation absorbed dose of 35 mrad. Multiple 191mIr angiograms can be performed, seconds to minutes apart, without interference from background. The 15.4-day t1/2 of 191Os permits transportation of the generator to centers far from the production facility. With the low radiation dose, high information density and the ability to repeat studies with 191mIr, clinical use of radionuclide angiography should be expanded.

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