Comparison of the Cardiovascular Actions of Org NC 45 with Those Produced By Other Non-Depolarizing Neuromuscular Blocking Agents in Experimental Animals

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Abstract
The cardiovascular actions of 1-[(2.beta.,3.alpha.,16.beta.,17.beta.)-3,17-bis(acetyloxy)-2-(1-piperidinyl)-androstan-16-yl]-1-methyl-piperidinium bromide (Org NC 45) are reviewed and compared with those of other non-depolarizing neuromuscular blocking drugs. Results obtained in anesthetized cats and dogs demonstrate that, in contrast to other neuromuscular blocking drugs, Org NC 45, even in doses 20 times greater than those required for neuromuscular block, has no effects on heart rate, arterial pressure, autonomic ganglia, adrenoceptors or baroreceptor activity. Studied in pithed rats and on guinea pig atria show that Org NC 45 has little effect on cardiac muscarinic receptors or on noradrenaline [norepinephrine] re-uptake mechanisms. Apparently, Org NC 45 possesses significant advantages over presently used non-depolarizing neuromuscular blocking drugs, since its clinical use should not be associated with cardiovascular side-effects. [Other drugs studied included pancuronium, metocurine, d-tubocurarine, gallamine, atropine, chandonium and fazadinium.].