A Knockout of a Transgenic Mouse — Animal Models of Sickle Cell Anemia
- 16 July 1998
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 339 (3) , 194-195
- https://doi.org/10.1056/nejm199807163390310
Abstract
Animal models of sickle cell anemia can be used to improve understanding of the pathophysiology of the disease, aid in the development of antisickling drugs, and test the feasibility of gene therapy. The basis of these interesting models is transgenic technology, in which foreign genes are introduced into the germ line of a mouse. With this method it is possible to create mice that carry the mutant sickle, or βS, gene and a normal human α-globin gene. In such animals, the human βS and α-globin genes code for sickle hemoglobin (α2βS 2), but . . .This publication has 5 references indexed in Scilit:
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