Further Observations on Mental Disturbances Associated with Cortisone and ACTH Therapy

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Abstract
A PREVIOUS paper described in detail the clinical and laboratory aspects of 10 cases in which mental disturbances of varying severity developed during treatment with cortisone or ACTH.1 The primary intention of that report was to characterize the natural history and symptomatology of this syndrome. To give a more exact description, cases that failed to demonstrate a clear relation between hormone administration and the occurrence of psychiatric complications were excluded. For example, none had a past history of overt psychiatric illness or nervous-system disease, none had known endocrinologic dysfunction, and none coincidentally received nonhormonal drugs or suffered metabolic dyscrasias to . . .