Studies on the Aliphatic Amines in Human Urine. I. : On the Determination of Aliphatic Primary Amines with Amino Acid Analyzer and Its Application to the Urine of Patients

1 January 1969

journal article
Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI

Vol. 89 (3) , 399-402
https://doi.org/10.1248/yakushi1947.89.3_399

Abstract

A method of separatory determination of aliphatic primary amines excreted in human urine was established with the amino acid analyzer, This method was applied to the determination of aliphatic primary amines in the distillate of amine concentrate prepared from urines of normal persons and patients. It was clarified that urinary excretion of ethanolamine and methylamine increased in liver diseases but remarkably decreased in kidney diseases. No difference was observed in diabetes mellitus as compared with normal persons. n-Propylamine and isopropylamine detected qualitatively by thin-layer chromatography by others were not found in our experiments.

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