A note on suxamethonium sensitivity and serum cholinesterase variants
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 32 (1) , 85-88
- https://doi.org/10.1007/bf00569981
Abstract
Sera from 21 cases of prolonged apnoea which showed normal phenotype (UU) on the basis of dibucaine and fluoride inhibition were re-examined by replacing the substrate benzoylcholine with succinylcholine (suxamethonium). 9 samples had normal enzyme activity but low dibucaine number (DN=<20) indicating the atypical variant; 6 sera showed no detectable enzyme activity. The remaining 6 samples had enzyme activity and DN comparable with healthy controls. The occurence of new variants of serum cholinesterase sensitive only to succinylcholine is suggested.This publication has 16 references indexed in Scilit:
- SUXAMETHONIUM SENSITIVITYAnnals of the New York Academy of Sciences, 1971
- New biochemical and immunological data on quantitative and qualitative variability of human pseudocholinesteraseHuman Genetics, 1971
- Heterogeneity in the silent gene phenotype of pseudocholinesterase of human serumBiochemical Genetics, 1970
- EVIDENCE FOR DIFFERENT “SILENT GENES” IN THE HUMAN SERUM PSEUDOCHOLINESTERASE POLYMORPHISMAnnals of the New York Academy of Sciences, 1968
- A Study of the Pseudocholinesterase in 78 Cases of Apnoea Following SuxamethoniumHuman Heredity, 1966
- Studies on formal genetics of the pseudo-cholinesterase∗∗Acylcholine-acylhydrolase, E C 3.1.1.8. polymorphism; An atypical segregation in a familyBiochemical Pharmacology, 1964
- The Relation Between Plasma Cholinesterase and Prolonged Apnea Caused by SuccinylcholineAnesthesiology, 1963
- Differential Inhibition of Human Serum Cholinesterase with Fluoride: Recognition of Two New PhenotypesNature, 1961
- THE FAMILIAL INCIDENCE OF LOW PSEUDOCHOLINESTERASE LEVELThe Lancet, 1956
- SuccinylmonocholineBMJ, 1953