Trehalose Dimycolate Enhances Survival of Fission Neutron-Irradiated Mice and Klebsiella pneumoniae-Challenged Irradiated Mice
- 1 January 1990
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 121 (1) , 71-75
- https://doi.org/10.2307/3577566
Abstract
The survial of B6D2F1 female mice exposed to lethal doses of fission neturon radiation is increased when trehalose dimycolate (TDM) preparations are given either 1 h after exposure or 1 day before exposure to radiation. TDM in an emulsion of squalene, Tween 80, and saline was the most effective formulation for increasing the 30-day survival of mice when given 1 day before (90%) or 1 h after (88%) exposure to radiation. An aqueous suspension of a synthetic analog of TDM was less effective at increasing 30-day survival (60%) when given 1 day prior to radiation exposure and not effective when given 1 hr after radiation. Mice receiving a sublethal dose (3.5 Gy) of fission neutron radiation and either the TDM emulsion or synthetic TDM 1 h after irradiation were substantially more resistant to challenge with 10, 100, 1000, or 5000 times the LD50/30 dose of Klebsiella pneumoniae than untreated mice.This publication has 1 reference indexed in Scilit:
- Genetic injury in hybrid male mice exposed to low doses of 60Co γ-rays or fission neutrons III. Frequencies of abnormal sperm and reciprocal translocations measured during and following long-term weekly exposuresMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988