Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol

Open Access

1 March 1988

journal article
research article
Published by Wiley in Arthritis & Rheumatism

Vol. 31 (3) , 436-440
https://doi.org/10.1002/art.1780310318

Abstract

Six of 9 patients with previously documented adverse reactions to allopurinol exhibited transformation of their peripheral blood lymphocytes when these were exposed in vitro to the allopurinol metabolite, oxypurinol. In 2 of these subjects, intradermal skin challenge was positive at 48 hours with either allopurinol or oxypurinol. The evidence presented suggests that some adverse reactions to allopurinol represent delayed-type hypersensitivity to oxypurinol.

Keywords

ADVERSE REACTION

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