STRUCTURAL STUDIES OF H-2D PRODUCTS OF MOUSE MUTANT BALB-C-H-2DDB AND PARENTAL STRAIN BALB-CKHH-2DD
- 1 January 1978
- journal article
- research article
- Vol. 121 (3) , 869-871
Abstract
The tryptic peptide profile characteristics of the H-2D glycoprotein, isolated by immunoprecipitation from the MCH [major histocompatibility complex] mutant mouse strain BALB/c-H-2Ddb, were compared with those of the H-2D molecule from the parent strain BALB/cKh-H-2Dd. At each stage of purification these molecules exhibited identical biochemical properties and on peptide mapping it was observed that the Ddb molecule showed no detectable peptide differences from the D1d molecule of the nonmutant parent. The site of mutation in this mutant strain, although located in the D region of the MHC, is distinct from the gene coding for molecules bearing the H-2.4 private specificity.This publication has 0 references indexed in Scilit: