Tumorigenic potential of endoperoxide analogs
- 1 February 1984
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 40 (2) , 209-211
- https://doi.org/10.1007/bf01963604
Abstract
The endoperoxide analogs known as U-46619 and U-44069 significantly enhanced the carcinoma formation and cellular atypicality initiated by a chemical carcinogen in mice. Studies of DNA radioactivity demonstrated that endoperoxides exerted their cocarcinogenic action by stimulating DNA synthesis. Thus, they play an important role in tumor cell proliferation.Keywords
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