Cross-link in Fibrin Polymerized by Factor XIII: ε-(γ-Glutamyl)lysine
- 24 May 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 160 (3830) , 892-893
- https://doi.org/10.1126/science.160.3830.892
Abstract
ε-(γ-Glutamyl)lysine has been isolated from enzymatic hydrolyzates of cross-linked human fibrin. This compound was not detected in "non-cross-linked" fibrin prepared with ethylenediaminetetraacetic acid, which inhibits factor XIII; intermediate amounts were observed when the fibrin was prepared with glycine ethyl ester, which inhibits factor XIII competitively. These and ancillary experiments furnish conclusive evidence that ε-(γ-glutamyl)lysine cross-links form in human fibrin during polymerization catalyzed by factor XIII.This publication has 22 references indexed in Scilit:
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