Relationship Between Long Durations and Different Regimens of Hormone Therapy and Risk of Breast Cancer
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Open Access
- 25 June 2003
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 289 (24) , 3254-3263
- https://doi.org/10.1001/jama.289.24.3254
Abstract
There is considerable evidence from observational studies,1 and now from a randomized controlled trial, the Women's Health Initiative (WHI),2 that use of combined estrogen and progestin hormone replacement therapy (CHRT) is associated with an increased risk of breast cancer. Specifically, a pooled analysis of 51 observational studies found that current users of CHRT or progestin alone for 5 years or longer had a 53% increase in risk of breast cancer,1 and after 5.2 years of follow-up the WHI reported that CHRT was associated with a statistically nonsignificant 26% increase in breast cancer risk.2Keywords
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