CEREBRAL BLOOD-FLOW TOMOGRAPHY - XE-133 COMPARED WITH ISOPROPYL-AMPHETAMINE-IODINE-123 - CONCISE COMMUNICATION

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 24  (1) , 17-21
Abstract
Tomographic maps of local cerebral blood flow (CBF) were obtained with 133Xe and with isopropyl-amphetamine 123I (IMP) in 11 subjects: 1 normal, 2 tumor cases and 8 cerebrovascular cases. A highly sensitive 4-face, rapidly rotating, single-photon emission tomograph was used. The 133Xe flow maps are essentially based on the average 133 concentration over the initial 2 min during and after an inhalation of the inert gas lasting 1 min. These maps agreed very well with the early IMP maps obtained over the initial 10 min following an i.v. bolus injection. The subsequent IMP tomograms showed a slight decrease in contrast amounting to .apprx. 5 percentage points in the CBF ratio between diseased and contralateral areas. Apparently, 133Xe is more practical: low cost, available on a 7-day basis, easily repeatable, quantifiable without the need for arterial sampling, and with low radiation exposure to patient and personnel. IMP gives an image of slightly higher resolution. It also introduces a new class of iodinated brain-seeking compounds allowing, perhaps, imaging of other functions more important than mere blood flow.