The Effect of Tritiated Thymidine on Mortality and Tumor Incidence in Mice

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Abstract
In an investigation of the late effects of tritiated thymidine in the Brookhaven National Laboratory strain of Swiss albino mice, this compound (specific activity 1.9 Ci/mmole) was injected intraperitoneally into female animals 6 to 12 weeks of age. Three hundred animals received 5 [mu]Ci/gm of body weight, another 300 received 1 [mu]Ci/gm of body weight, 300 served as controls, and 100 served as radiation controls, receiving 400 R of gamma-radiation. Animals were allowed to live out their full life spans, which were recorded along with autopsy findings. Mean life spans and age-specific mortality rates of mice injected with tritiated thymidine were indistinguishable from those of control animals. There was no measurable alteration in tumor incidence, tumor type, or time of onset of neoplasia that could be attributed to the injection of this compound.

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