Identity‐by‐descent analysis of sibship configurations

1 October 1985

journal article
research article
Published by Wiley in American Journal of Medical Genetics

Vol. 22 (2) , 263-272
https://doi.org/10.1002/ajmg.1320220207

Abstract

This study considers configurations of identity‐by‐descent sharing in sibships as an alternative to breaking the sibship into sib pairs. A general method is presented for specifying all distinct configurations and deriving their probabilities. The method works for sibships of arbitrary size and can be implemented with paper and pencil. Specific results are given for sibships up to size six. Applications for disease‐marker studies are discussed.

Keywords

This publication has 6 references indexed in Scilit:

THE AFFECTED SIB METHOD. I. STATISTICAL FEATURES OF THE AFFECTED SIB-PAIR METHOD
Genetics, 1985
The information contained in multiple sibling pairs
Genetic Epidemiology, 1984
A search for heterogeneity in insulin dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families
Metabolism, 1983
Power of the affected-sib-pair method to detect disease susceptibility loci of small effect: An application to multiple sclerosis
American Journal of Medical Genetics, 1982
A simple method to detect linkage for rare recessive diseases: An application to juvenile diabetes
Clinical Genetics, 1979
The generalized sib pair IBD distribution: its use in the detection of linkage
Annals of Human Genetics, 1978