Effects of Histamine on Transport (Na+-K+-Dependent) ATPase System (EC 3.6.1.3) Prepared from Human Gastric Mucosa

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Abstract
The transport (membrane, Na+-K+-stimulated or Na+-K+-dependent) ATPase (EC 3.6.1.3) was prepared from fundic gastric mucosa of operated patients and the histamine effect was studied on its activity. It has been observed that histamine significantly stimulated the Mg2+-dependent part, on the one hand, and inhibited the total and Na+-K+-dependent ATPase activity from membrane fractions of human gastric mucosa, on the other hand. The interrelationship between the transport ATPase system and the adenyl cyclase system, at the level of the cell membrane, is reviewed.

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