Immunization against Poliomyelitis with Living Attenuated Virus

Publisher Website
Google Scholar
Abstract
“No man can answer for his courage who has never been in danger.” LaRoche The immunization of man against poliomyelitis with preparations of living attenuated virus has been practiced by myself and my associates for the past five and one-half years (Koprowski et al., 1952). All the results of the study cannot even be summarized in this lecture and, while I shall review some past events, I intend to concentrate on taking an inventory of the present. Strains of virus. Three attenuated strains of virus have been used for the immunization of human subjects: two, the TN strain (Koprowski et al., 1952) and MEF1 strain (Roca-Garcia et al., 1952; Roca-Garcia and Jervis, 1955) represent Type II, and one, the SM strain (Koprowski et al., 1954a), represents Type I. The TN strain is a rodent-adapted virus.