Preparation of paraherquamide labeled with deuterium or tritium
- 1 April 1990
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 28 (4) , 461-464
- https://doi.org/10.1002/jlcr.2580280414
Abstract
Deprotonation of paraherquamide (1a) at C‐24 and subsequent deuteration (or tritiation) is described. The procedure afforded 24‐2H‐paraherquamide (1b) with 66% deuterium incorporation at C‐24. Modification of the deuteration procedure to allow the introduction of tritium resulted in the preparation of 24‐3H‐paraherquamide (1c) with specific activity 3.7 Ci/mmol.Keywords
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