Alloimmunisation to HLA Antigens following Transfusion with Leucocyte‐Poor and Purified Platelet Suspensions
- 1 November 1985
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 49 (5) , 331-335
- https://doi.org/10.1111/j.1423-0410.1985.tb00807.x
Abstract
24 previously non‐transfused patients were given three transfusions of 200 times 108 platelets at 14‐day intervals. Group I (12 patients) received leucocyte‐poor platelet suspensions with a mean contamination of 15 times 106 leucocytes per transfusion. Group II (12 patients) received platelets with 6 leucocytes per transfusion. 5 patients in group I and no patients in group II developed lymphocytotoxic antibodies (p == 0.037). Platelets with fewer than 5 times 106 leucocytes did not seem to stimulate a response to major histocompatibility antigens, but with a small contaminating dose of leucocytes appeared to be highly immunogenic.This publication has 12 references indexed in Scilit:
- The effect of pretransplant platelet transfusions on renal allograft survival and sensitization in dogs1Tissue Antigens, 1985
- Importance of White Blood Cells in Platelet Storage1Vox Sanguinis, 1984
- LACK OF BENEFICIAL EFFECT OF THROMBOCYTE TRANSFUSIONS ON KIDNEY GRAFT SURVIVAL IN DOGSTransplantation, 1984
- IMMUNOLOGICAL UNRESPONSIVENESS INDUCED BY PLATELET TRANSFUSION IN RHESUS MONKEYS1Transplantation, 1983
- ALLOGENEIC PLATELETS INCREASE THE SURVIVAL OF RAT RENAL ALLOGRAFTSTransplantation, 1983
- Leukocyte‐depleted blood A comparison of filtration techniquesTransfusion, 1983
- Deliberate Donor-specific Blood Transfusions Prior to Living Related Renal TransplantationAnnals of Surgery, 1980
- Matching of blood platelets for transfusionAmerican Journal of Hematology, 1978
- Anti‐HL‐A Antibody Evolution in Recipients of Planned TransfusionsTissue Antigens, 1972
- The Production of Anti HL‐A Cytotoxic Antisera Through Planned Immunization by Intravenous Injection of Small Aliquots of Whole BloodTissue Antigens, 1972