Developmental changes of myelin-related lipids in brain of miniature swine

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Abstract
The biochemical development of whole brains from male and female miniature swine aged 2 weeks to 1 years was studied. The data were similar for both sexes. The brain-body weight ratio declined rapidly for the first 10–12 weeks after birth, then decreased at a slower rate up to 1 year. Total brain lipid weight and lipid phosphorus changed rapidly during the first 8–10 weeks of life, but thereafter changed very little. The glycolipid content rapidly increased during the first 12–14 weeks of life and then increased at a slower rate. Total brain cholesterol increased continuously over the time period studied, although the rate of increase appeared to decline with age. Monogalactosyl diacylglycerol concentration remained constant up to about 8 weeks of age, but then decreased continuously up to 1 year. The alkali-labile fatty acid composition of pig brain remained relatively constant except for increases in 18∶1 and 22∶6(n − 3) and a decrease in 16∶0. The increase in percentage of 18∶1 was most rapid during the first 10 weeks of age. These data suggest that the “growth spurt” or active myelination phase of miniature pig brain development ends at 8–10 weeks post partum.

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