Significance of Mutations in embB Codon 306 for Prediction of Ethambutol Resistance in Clinical Mycobacterium tuberculosis Isolates
- 1 May 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (5) , 1900-2
- https://doi.org/10.1128/aac.50.5.1900-1902.2006
Abstract
We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 ( embB 306). Mutations were detected only in EMB-resistant strains ( n = 69; 68%), thus confirming the significance of embB 306 mutations for the prediction of resistance to EMB.Keywords
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