Risk Factors for Delirium at Discharge

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Abstract
Delirium represents a common, serious, and potentially preventable problem for older persons.1 Previous work has emphasized its transient nature; however, recent studies document that up to 50% of delirium persists until hospital discharge and often for months beyond.2-8 Persistent delirium has been associated with worse long-term cognitive and functional outcomes than resolved delirium.6,9 Delirium may be more persistent in persons with underlying dementia.4,6,8,10 Moreover, several precipitating factors for delirium may not be completely reversible (eg, those resulting in neuronal injury).11 Many experts believe that persistent delirium may directly contribute to dementia.11-13 Thus, understanding factors that lead to persistent delirium will help to clarify the pathways by which delirium may lead to long-lasting cognitive sequelae.