EFFECT OF LUNG DENERVATION ON DEVELOPMENT OF PULMONARY-EDEMA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 89  (5) , 617-621
Abstract
Relationship of an intact nervous system to the lung in the development of pulmonary edema was studied. After unilateral denervation of a lung by autotransplantation, 8 dogs were subjected to a period of increased intracranial pressure with air. A significant increase in pulmonary artery pressure and a 20% right-to-left shunt developed in all animals. The innervated lung of the animals subjected to increased intracranial pressure developed higher wet/dry lung weight ratios and 51Cr platelet counts compared to denervated lungs and to the 5 control innervated lungs. Intrapulmonary platelet sequestration and pulmonary edema occurred only in the intact innervated lung. Apparently, pulmonary edema following elevation of the intracranial pressure with air is due to neurally induced alterations in pulmonary hemodynamics and platelet sequestration that could possibly lead to an increase in pulmonary vascular permeability.

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