Bile Acids: A pH Dependent Antibacterial System in the Gut?
- 30 September 1972
- Vol. 3 (5830) , 813-815
- https://doi.org/10.1136/bmj.3.5830.813
Abstract
Bile acids are secreted in the bile in the form of conjugates and many species of intestinal bacteria can rapidly deconjugate them. Studies have shown that an unconjugated bile acid may have bactericidal and bacteriostatic effects, which are pH dependent. It is proposed that unconjugated bile acids may be involved in a homoeostatic mechanism, preventing bacterial growth in the small intestine.Keywords
This publication has 13 references indexed in Scilit:
- Resistance Of Vegetative Cells Of Clostridium Welchii To Low PhJournal of Medical Microbiology, 1971
- Bile Acid inhibition of the intestinal microflora—A function for simple bile acids?Gastroenterology, 1971
- BACTERIA AND qTIOLOGY OF CANCER OF LARGE BOWELThe Lancet, 1971
- Bile salt metabolism in the normal human small intestine.1970
- Bacteria, bile and the small bowelGut, 1969
- Studies on the intestinal flora : Part II Bacterial flora of the small intestine in patients with gastrointestinal disordersGut, 1969
- BILE-SALTS IN SMALL INTESTINAL CONTENTS AFTER ILEAL RESECTION AND IN OTHER MALABSORPTION SYNDROMESThe Lancet, 1968
- Partial biliary obstruction with cholangitis producing a blind loop syndrome.Gut, 1968
- Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora.1967
- JEJUNAL BACTERIOLOGY AND BILE-SALT METABOLISM IN PATIENTS WITH INTESTINAL MALABSORPTIONThe Lancet, 1966