Self-Reported Race and Genetic Admixture

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Abstract
The use of data on self-reported race in health research has been highly debated.1,2 For example, Burchard et al. recently argued that important information on disease susceptibility may be derived from the use of data on self-reported race,1 whereas Cooper et al.2 cited Wilson et al.,3 who argued that ethnic labels “are inaccurate representations of the inferred genetic clusters.” Cooper et al., however, ignored later work4 that identified limitations in the analyses of Wilson et al. — specifically, inappropriate classification of groups, the use of a suboptimal model for cluster identification, and reliance on only 39 microsatellite markers for cluster analyses. With larger numbers of markers, it was shown that genetically distinct groups can be almost completely inferred from self-reported race.5

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