Fatty Acids and Their Prostaglandin Derivatives: Inhibitors of Proliferation in Aortic Smooth Muscle Cells
- 15 July 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4300) , 289-291
- https://doi.org/10.1126/science.877555
Abstract
Prostaglandins are synthesized from eicosa-8,11,14-trienoic acid and eicosa-5,8,11-14-tetraenoic acid by smooth muscle cell cultures from guinea pig aorta. Production is inhibited by indomethacin. The precursor fatty acids and their prostaglandin derivatives inhibit proliferation of the cell cultures. The relative availability of fatty acids for prostaglandin biosynthesis may represent a control mechanism for cell proliferation.This publication has 12 references indexed in Scilit:
- The induction of atherosclerotic plaque-like mounds in cultures of aortic smooth muscle cellsVirchows Archiv B Cell Pathology, 1975
- ProstaglandinsAnnual Review of Biochemistry, 1975
- Cyclic GMP and cyclic AMP levels in normal and transformed fibroblastsNature, 1974
- Metabolic Alterations of Fatty AcidsAnnual Review of Biochemistry, 1974
- The relationship between concentration of prostaglandin E and rates of cell replicationExperimental Cell Research, 1974
- Atherosclerosis and the Arterial Smooth Muscle CellScience, 1973
- Regulation of Cell Growth by Cyclic Adenosine 3′,5′-MonophosphatePublished by Elsevier ,1972
- Prostaglandin production by mouse fibrosarcoma cells in culture: Inhibition by indomethacin and aspirinBiochemical and Biophysical Research Communications, 1972
- Specificities of Prostaglandins B1, F1α, and F2α Antigen-Antibody ReactionsPublished by Elsevier ,1971
- Position of double bonds in the fatty acids of cholesterol esters from human aortaAtherosclerosis, 1970