The Stomach Speaks — Ghrelin and Weight Regulation

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Abstract
Recent years have witnessed explosive growth in knowledge of the physiologic factors regulating appetite and body weight.1 Among these are neural, metabolic, and endocrine signals from the periphery that reflect the short- and long-term status of energy balance and a central neural network centered in the hypothalamus that receives and integrates these signals and orchestrates appropriate responses of appetite and energy expenditure. Satiety signals are divided into those that influence the termination of individual meals and those that relate to the long-term regulation of body weight, although these systems overlap. Not surprisingly, satiety resulting from individual meals involves the gut, . . .