Stimulation of DNA synthesis but not of peroxisomal ?-oxidation by nafenopin in primary cultures of marmoset hepatocytes
- 1 December 1988
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 12 (12) , 1077-1087
- https://doi.org/10.1016/0309-1651(88)90032-x
Abstract
The effects of the peroxisome proliferator nafenopin upon primary cultures of marmoset hepatocytes have been investigated and compared to those on cultured rat hepatocytes. Nafenopin did not induce peroxisomal .beta.-oxidation or peroxisome proliferation but did induce replicative DNA synthesis. These findings demonstrate that peroxisome proliferation and mitogenicity are two independent properties of nafenopin and question the widely held view that primates are generally insensitive to the effects of peroxisome proliferators.This publication has 8 references indexed in Scilit:
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