PROSTAGLANDIN SYNTHETASE SYSTEMS IN RAT AND RABBIT RENAL MEDULLA AND INHIBITION BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
Open Access
- 1 January 1977
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 27 (3) , 351-359
- https://doi.org/10.1254/jjp.27.351
Abstract
The properties of prostaglandin synthetase systems (PSS) in the renal medulla of the rat and rabbit, and inhibition by ketoprofen, indomethacin, ibuprofen, phenylbutazone and aspirin were investigated in relation to their anti-inflammatory, analgesic, antipyretic and ulcerogenic activities. Rat and rabbit PSS produced prostaglandin (PG)E and PGF from arachidonic and dihomo-.gamma.-linolenic acids and had an optimal pH of 8.5 and 7.5 for PGE formation, respectively. Only a slight loss of activity occurred with lyophilization. In the rat PSS all drugs tested were inhibitory in the order of ketoprofen, ibuprofen, indomethacin and aspirin, respectively. In the rabbit PSS the same potency relationship was also found. Drug sensitivity of the rat PSS was remarkably lower than that of the rabbit PSS. Significant correlations were noted between the inhibitory potencies of the drugs against both PSS and other in vivo pharmacological activities within the same species.This publication has 22 references indexed in Scilit:
- Correlation between inhibition by anti-inflammatory substances, of arachidonic acid-induced hypotension and of prostaglandin biosynthesis in vitroBiochemical Pharmacology, 1976
- Correlation between anti-inflammatory properties and inhibition of prostaglandin biosynthesis in vitroBiochemical Pharmacology, 1975
- Diclofenac sodium (GP 45840, voltaren), a potent inhibitor of prostaglandin synthetaseBiochemical Pharmacology, 1975
- Production of an inflammatory exudate containing prostaglandinsJournal of Pharmacy and Pharmacology, 1974
- New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory DrugsAnnual Review of Pharmacology, 1974
- Prostaglandins, Aspirin-like Drugs and the Oedema of InflammationNature, 1973
- Prostaglandins as Potentiators of Increased Vascular Permeability in InflammationNature, 1973
- Prostaglandins and anti-inflammatory drugs in the dog knee jointJournal of Pharmacy and Pharmacology, 1972
- Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugsBiochemical and Biophysical Research Communications, 1972
- Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusionJournal of Pharmacy and Pharmacology, 1969