Drug-Induced Tolerance: Selective Induction with Immunosuppressive Drugs and Their Synergistic Interaction
- 1 January 1975
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 48 (2) , 248-260
- https://doi.org/10.1159/000231311
Abstract
Drug-induced tolerance to polyinosinic·polycytidylic acid was studied in NZB/W mice. A single injection of cyclophosphamide (CY) or methotrexate (MTX) induced tolerance when given 24 h after antigen, whereas azathioprine (AZ) and methylprednisolone (MP) did not. However, MP and MTX each synergized with a nontolerogenic dose of CY. In addition, MP and AZ further reduced the tolerance induced by low but tolerogenic doses of CY. Drug combinations in the induction of tolerance may have wide application in the fields of clinical immunology and transplantation.Keywords
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