REGULATION OF PLASMA OESTROGENS IN NORMAL ADULT MALES

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Abstract
The response of plasma oestradiol (Oe2), oestrone (Oe1), testosterone (T) and cortisol to dexamethasone and ACTH administration in normal adult males was ascertained. After an oral dose of 1.5 mg dexamethasone Oe1 decreased from 2.51 to 1.85 ng/100 ml (74 % of the control level, mean of 15 subjects) over night and after continuing the dexamethasone administration for two more days (twice daily 1.5 mg) Oe1 decreased to 1.30 ng/100 ml (52 %). Oe2 (control level 1.71 ng/100 ml) and T (678 ng/100 ml) did not change over night, but at the end of the test Oe2 decreased to 84 % and T to 91 % of the control level. After a single im injection of 2 mg β 1–24 cortrophin Oe1 increased 1.9 times (mean of 13 subjects) without further increase during two more days of treatment (twice daily 1 mg), while Oe2 did not change over night and decreased to 75 % of the control level at the end of the test. Under ACTH T decreased to 66% of the control level over night and to 50% at the end of the test indicating a suppression of the testicular hormone secretion. From these results and those reported previously it was concluded that the testicular hormone secretion influences mainly Oe2 in peripheral plasma, while Oe1 depends mainly on the adrenal hormone secretion.

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