The significance of the complement system for the pathogenesis of age-related macular degeneration — current evidence and translation into clinical application
Open Access
- 3 December 2010
- journal article
- review article
- Published by Springer Nature in Albrecht von Graefes Archiv für Ophthalmologie
- Vol. 249 (2) , 163-174
- https://doi.org/10.1007/s00417-010-1568-6
Abstract
Dysregulation of the complement system has been shown to play a major role in the pathogenesis of age-related macular degeneration (AMD).Keywords
This publication has 117 references indexed in Scilit:
- Progression of Geographic Atrophy and Genotype in Age-Related Macular DegenerationOphthalmology, 2010
- Three Major Loci Involved in Age-Related Macular Degeneration Are Also Associated with Polypoidal Choroidal VasculopathyOphthalmology, 2010
- Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants With Respect to Phenotype in Advanced Age-Related Macular DegenerationAmerican Journal of Ophthalmology, 2009
- The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visitedPublished by Elsevier ,2009
- Molecular pathology of age-related macular degenerationProgress in Retinal and Eye Research, 2009
- Age-related macular degenerationThe Lancet, 2008
- Variation near complement factor I is associated with risk of advanced AMDEuropean Journal of Human Genetics, 2008
- Basal Laminar Drusen Caused by Compound Heterozygous Variants in the CFH GeneAmerican Journal of Human Genetics, 2008
- Clinical Phenotypes Associated with the Complement Factor H Y402H Variant in Age-related Macular DegenerationAmerican Journal of Ophthalmology, 2007
- Cigarette Smoking, CFH, APOE, ELOVL4, and Risk of Neovascular Age-Related Macular DegenerationArchives of Ophthalmology (1950), 2007