Structural Identification of Thrombosthenin in Rat Megakaryocytes

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Abstract
An abundance of filamentous material was seen in the cytoplasm of megakaryocytes after treatment of rat red bone marrow with a glycerol/standard salt solution. The filaments measured 50–120 Å in thickness and were especially abundant in the cells' periphery and in cytoplasmic extensions of thrombocytogenic megakaryocytes, and the filaments were morphologically identical to the contractile proteins (thrombosthenin) seen in platelets. Heavy meromyosin binding was used as a criterion to identify the actinoid filaments.