Effects of Nitric Oxide Synthase Inhibition on Phospholipid Fatty Acid Composition of Brown Adipose Tissue.
Open Access
- 1 January 1997
- journal article
- Published by Physiological Society of Japan in The Japanese Journal of Physiology
- Vol. 47 (5) , 477-480
- https://doi.org/10.2170/jjphysiol.47.477
Abstract
We investigated the effects of nitric oxide synthase inhibition on the phospholipid fatty acid composition of brown adipose tissue by administering chronic N omega-nitro-L-arginine methyl ester (L-NAME) (0.01%) to rats via drinking water. L-NAME caused a significant decrease in C14:0, C16:0, C16:1 and C18:1, with a concomitant increase in C18:0 and C18:2, L-NAME treatment elicited an increase in the unsaturation index. There were no significant changes in other fatty acids including the polyunsaturated fatty acids docosahexaenoate (DHA, C22:6) and arachidonate (C20:4). Polyunsaturated fatty acid linoleate (C18:2) was increased and the arachidonate index decreased in the L-NAME-treated group, suggesting a diminished conversion of C18:2 to C20:4.Keywords
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