Long-Lasting Binding of IT-066 to Human Histamine H2 Receptor
- 1 January 2000
- journal article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 45 (4) , 796-801
- https://doi.org/10.1023/a:1005464231214
Abstract
Based on animal models, IT-066, a histamine H2-receptor antagonist, is reported to possess potent and long-lasting antagonisms on histamine H2 receptor (H2R) -mediated effects. However, no reports...Keywords
This publication has 17 references indexed in Scilit:
- Structure–Activity Characterization of an H2-Receptor Antagonist, 3-Amino-4-[4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1,2-dione Hydrochloride (IT-066), Involved in the Insurmountable Antagonism against Histamine-Induced Positive Chronotropic Action in Guinea Pig AtriaBiochemical Pharmacology, 1998
- The C Terminal Tail of the Histamine H2 Receptor Contains Positive and Negative Signals Important for Signal Transduction and Receptor Down‐RegulationJournal of Neurochemistry, 1996
- Two Distinct Pathways for Histamine H2 Receptor Down-regulationPublished by Elsevier ,1996
- Desensitization of Canine Histamine H2 Receptor Expressed in Chinese Hamster Ovary CellsBiochemical and Biophysical Research Communications, 1993
- Molecular cloning of the human histamine H2 receptorBiochemical and Biophysical Research Communications, 1991
- Pharmacokinetic and Pharmacodynamic Properties of Histamine H2-Receptor AntagonistsClinical Pharmacokinetics, 1991
- Molecular cloning of a gene encoding the histamine H2 receptor.Proceedings of the National Academy of Sciences, 1991
- Time-Dependent Interaction of a New H2-Receptor Antagonist, IT-066, with the Receptor in the Atria of Guinea PigThe Japanese Journal of Pharmacology, 1991
- H2-receptor antagonism by a novel compound IT-066 assessed from [14C]aminopyrine accumulation in rabbit parietal cellsEuropean Journal of Pharmacology, 1990
- Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortexNature, 1983