The mechanism of inhibition of cholinesterases by organophosphorus compounds
- 1 December 1953
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 55 (5) , 763-766
- https://doi.org/10.1042/bj0550763
Abstract
Reaction of organophosphorus inhibitors of the general formula (R)2(X)PO, where X is the group labile to hydrolysis with cholinesterase produces the same inhibited enzyme provided the R groups are maintained constant even though X is varied. This is a direct confirmation of the phosphorylation mechanism for inhibition.Keywords
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