EVIDENCE FOR THE UTILIZATION OF PREFORMED PURINES BY RAT LYMPHOID TISSUES: IMPLICATION TO IMMUNOSUPPRESSION BY 6‐THIOPURINE ANALOGUES

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Abstract
Summary: Portal occlusion selectively inhibits the in vivo incorporation of [14C]formate into the purines of deoxyribonucleic acid isolated from rat lymph nodes and thymus compared with incorporation into deoxyribonucleic acid thymine. Incorporation of formate into deoxyribonucleic acid purines is also low in perfused submandibular lymph nodes and in lymph nodes incubated in vitro. A similar depression of formate incorporation into lymphoid tissue deoxyribonucleic acid purines is obtained by treatment with the immuno‐ suppressive drugs azathioprine and 9‐butylazathioprine.

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