In-vitro activity of pefloxacin against micro-organisms multiply resistant to -lactam antibiotics and aminoglycosides

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Abstract
The in-vitro activity of pefloxacin was evaluated against 360 Enterobacteriaceae, 143 Pseudomonas aeruginosa and 124 staphylococci, selected for multiply resistance to different β-lactam antibiotics and aminoglycosides. The MIC 90 of pefloxacin against staphylococci and most Enterobacteriaceae was 0.5 mg/1 or less. The MIC 90 against Serratia marcescens and P. aeruginosa varied between 4 and 8 mg/1. Time-killing curves showed that pefloxacin at concentrations of four times the MIC decreased the viable counts by 3 logs or more within 1–8 h.