Pharmacodynamics of mivacurium in infants
Open Access
- 1 October 1994
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 73 (4) , 490-493
- https://doi.org/10.1093/bja/73.4.490
Abstract
A computerized infusion system was used to determine mivacurium infusion requirements to maintain 95% and 50% neuromuscular block in 15 infants less than 1 yr of age. Neuromuscular block was measured by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50–100 μg kg−1 h−1. Neuromuscular block was produced by repeated bolus doses of mivacurium 0.1 mg kg−1; subsequently the target neuromuscular block was maintained by a closed loop infusion. Dose potency of mivacurium was similar to that previously published in children with a similar anaesthetic technique. Mean mivacurium requirement for 95% neuromuscular block was 820 (SD 300) μg kg−1 h−1, which represented an hourly requirement of 6.6 (1.5) individual ED95 doses. Infusion requirement for 50% neuromuscular block was 320 (150) μg kg−1 h−1. These infusion rates were similar to those in children. No side effects of mivacurium were noticed.Keywords
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