Enhancement of ethanol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors
- 1 November 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 28 (11) , 832-835
- https://doi.org/10.1111/j.2042-7158.1976.tb04066.x
Abstract
Male Swiss-Webster mice were made physically dependent on ethanol using the ethanol vapour inhalation technique. Animals pretreated with methysergide, a known 5-hydroxytryptamine receptor blocking agent, had significantly greater alcohol-induced withdrawal convulsions than saline pretreated controls. These findings suggest that the reduction of 5-HT at receptor sites may result in the augmentation of the withdrawal convulsions.This publication has 17 references indexed in Scilit:
- Ethanol narcosis in mice: Serotonergic involvementCellular and Molecular Life Sciences, 1974
- BIOGENIC AMINES AND HEAD TWITCHES IN MICE DURING ETHANOL WITHDRAWALBritish Journal of Pharmacology, 1974
- EFFECTS OF CATECHOLAMINE SYNTHESIS INHIBITION ON ETHANOL‐INDUCED WITHDRAWAL SYMPTOMS IN MICEBritish Journal of Pharmacology, 1974
- Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the ratPharmacology Biochemistry and Behavior, 1973
- Soporific action of ethanol in mice: Possible role of biogenic aminesPharmacology Biochemistry and Behavior, 1973
- REGIONAL DISTRIBUTION OF BRAIN 5‐HYDROXYTRYPTAMINE IN RAT STRAINS SELECTED FOR THEIR ALCOHOL INTAKE*Annals of the New York Academy of Sciences, 1973
- Synergy of Ethanol and Alcohol-Like Metabolites: Tryptophol and 3,4-DihydroxyphenylethanolPharmacology, 1973
- Pyrazole and ethanol potentiation of tryptophol-induced sleep in miceLife Sciences, 1971
- Histochemical Fluorescence of Raphe Neurons: Selective Enhancement by TryptophanScience, 1971
- The Direct Demonstration of a Barrier Mechanism in the Brain CapillariesActa Pharmacologica et Toxicologica, 1964