Simplex Optimization of Reaction Condition Using Laboratory Robotic System

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Abstract
An automated system was constructed for the optimization of the experimental conditions of a color developing reaction. This system consists of a laboratory robot system and a spectrophotometer which are connected with a personal computer by a remote control interface through RS-232C and by a GP-IB interface, respectively. The procedure for the color developing reaction was carried out with the robot system while the measurement of the absorbance of a sample and the transmission of the value to the computer were carried out automatically with a spectrophotometer. The personal computer controls the robot system and the spectrophotometer, and calculates the optimal value according to the super modified simplex (SMS) algorithm basedon the transmitted absorbance value. This ystem was applied to the reaction of phosphotungstic acid and the drugs with a phenothiazine ring in the molecule. The optimal conditions were searched for chlorpromazine hydrochloride and levomepromazine maleate.

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