First Clinical Trial with Iohexol in Myelography

Abstract
The 1st clinical trial with iohexol in lumbar myelography was carried out as an open, non-comparative study in 30 patients and was part of a multicenter trial. Iohexol doses of 10-15 ml (180 mg I/ml) were used and clinical and laboratory tests were performed before and during 48 h after myelography. Spinal repuncture 6 or 24 h after myelography was done in all patients. Only minor side effects of temporary duration were recorded in 8 patients. No seizures or spikes on EEG were seen. There was no significant increase in CSF parameters such as white cell counts, protein or IgG.