THE INFLUENCE OF DIETHYLSTILBESTROL ON ALLOXAN DIABETES PAIRED FEEDING EXPERIMENTS1

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Abstract
Alloxau-diabetic rats whose diabetes was stable were paired according to similarity of weights and blood sugar values. Diethylstilbestrol was administered either by injections or by pellet implantation to one rat of each of twelve pairs for a period of 21 days. Rats given diethylstilbestrol exhibited slight anorexia so the control rats were pair-fed. The reduced food intake caused a body wt. loss which, however, was more pronounced in animals receiving diethylstilbestrol. During non-fasting periods the blood sugar remained at the pretreatment level in animals receiving diethylstilbestrol but decreased somewhat in the controls. The urine volume and sugar decreased in both control and treated rats. Values for blood N.P.N. were similar and increased in both groups following a 24 hr. fast with a tendency for N.P.N. to be higher in treated rats. Liver glycogen was markedly increased following treatment with diethylstilbestrol. From the data presented it is not apparent that diethylstilbestrol is a diabetogenic agent or that it ameliorates diabetic symptoms in the rat. The fall in glycosuria may be associated with reduced food intake.