Abnormal protein fractions of cerebrospinal fluid demonstrated by starch gel electrophoresis

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Abstract
Protein fractions demonstrated by starch gel electrophoresis and designated by us as "fast gamma," "gamma proper-2," and "additional prealbumins" were seen in spinal fluids of patients with disorders of the nervous system. Fast gamma, which was found to be associated with proteolytic activity, was seen with a wide variety of disorders and gamma proper-2 mostly in multiple sclerosis; the additional prealbumins were seen in purulent meningitides. A selective relative increase of slow alpha-2 fractions was seen most frequently in the spinal fluid of patients suffering from sclerosing arterial disease.

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