Nonlinear regression on multiple-dose data
- 1 December 1979
- journal article
- research article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 7 (6) , 675-679
- https://doi.org/10.1007/bf01061214
Abstract
Two examples are given to show how Metzler's nonlinear regression program can be used to estimate parameters in a model with multiple dosing. The model of one example is a set of equations involving sums of exponentials, whereas the other model is a set of differential equations reflecting first order absorption and Michaelis-Menten excretion. In both cases no data were given in one of the dosing intervals.Keywords
This publication has 1 reference indexed in Scilit:
- Mathematical Formulation for Nonuniform Multiple DosingJournal of Pharmaceutical Sciences, 1975