M1 and M3 muscarinic receptors
- 1 March 1992
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 3 (3) , 276-278
- https://doi.org/10.1097/00001756-199203000-00016
Abstract
P-FLUORO-HEXAHYDRO-SILA-DIFENIDOL hydrochloride (p-F-HHSiD) (15, 30 μg) and pirenzepine (7.5, 15, 30 μg), which are highly selective M, and M1 muscarinic antagonists, respectively, were injected intracerebroventricularly into freely moving rats. p-F-HHSiD (30 μg) reduced wakefulness (W) (from 34.7 ± 3.1 to 24.9 ± 1.3 min) and increased slow wave sleep (SWS) (from 56.7 ± 2.4 to 67.2 ± 1.5 min); however, it did not modify desynchronized sleep (DS) latency and percentage in 6 h recordings. W and SWS were not affected by pirenzepine (7.5, 15, 30 μg) which decreased significantly DS amount but left unaffected DS latency. The results suggest that each muscarinic receptor subtype may induce different and specific changes in sleep phases and cortical desynchronization processes.Keywords
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