Maternal Alpha-Fetoprotein Screening for Down's Syndrome

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Abstract
Since 1866, when John Langdon Down described the syndrome1 that today bears his name, substantial progress has been made in the study of Down's syndrome in both the biomedical and psychoeducational arenas. Whereas the primary focus in the first 100 years after Down's report had been on phenotypic delineation of the syndrome and epidemiologic investigations, the past few decades have witnessed research efforts in the realms of biochemistry and cytogenetics and in numerous important domains of biomedicine and the behavioral sciences.The enormous progress in the education of affected children, including the introduction of early-intervention programs, the enactment of the . . .