Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog
- 1 November 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 7 (6) , 755-762
- https://doi.org/10.1093/cvr/7.6.755
Abstract
Bretylium, 5 mg/kg, administered to anaesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.Keywords
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